Non‐normality can facilitate pulsing in biomolecular circuits

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Non-normality can Facilitate Pulsing in Biomolecular Feedforward Loops

Non-normality can underlie pulse dynamics in many engineering contexts. However, its role in pulses generated in biomolecular contexts is generally unclear. Here, we address this issue using the mathematical tools of linear algebra and systems theory on simple computational models of biomolecular circuits. We find that nonnormality is present in standard models of feedforward loops. We used a g...

متن کامل

Functional roles of pulsing in genetic circuits.

A fundamental problem in biology is to understand how genetic circuits implement core cellular functions. Time-lapse microscopy techniques are beginning to provide a direct view of circuit dynamics in individual living cells. Unexpectedly, we are discovering that key transcription and regulatory factors pulse on and off repeatedly, and often stochastically, even when cells are maintained in con...

متن کامل

Nonnormality in Lyapunov Equations

Nonnormality in Lyapunov Equations

متن کامل

Animation: can it facilitate?

Graphics have been used since ancient times to portray things that are inherently spatiovisual, like maps and building plans. More recently, graphics have been used to portray things that are metaphorically spatiovisual, like graphs and organizational charts. The assumption is that graphics can facilitate comprehension, learning, memory, communication and inference. Assumptions aside, research ...

متن کامل

Quantitative Performance Bounds in Biomolecular Circuits due to Temperature Uncertainty

Performance of biomolecular circuits is affected by changes in temperature, due to its influence on underlying reaction rate parameters. While these performance variations have been estimated using Monte Carlo simulations, how to analytically bound them is generally unclear. To address this, we apply control-theoretic representations of uncertainty to examples of different biomolecular circuits...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: IET Systems Biology

سال: 2018

ISSN: 1751-8849,1751-8857

DOI: 10.1049/iet-syb.2018.0008